Endocrine Abstracts

Aim: To estimate further results of treatment and outcomes in patients with subacute thyroiditis observed in the period from 1993 to 2005 years.Materials and methods: 102 patients (84 women, 18 men) with confirmed De Quervain’s subacute thyroiditis (SAT) were investigated and the findings were analysed retrospectively (clinical features, ultrasonography, laboratory tests).Results: There were 102 patients in the cohort within t...

Introduction: Obesity is one of the most common endocrine disorders. Obesity can either be a symptom of numerous diseases or be associated with them, including cases, when patient does not have other complaints besides excess weight. This should be considered before initiating obesity treatment.Case: A 42-year-old male visited endocrinologist, complaining of overweight. Minimum weight from his adulthood was 70 kg, maximum was for that moment–124.5 k...

Introductionsome authors propose to conduct consistently two additional tests for differential diagnosis (DD) of NDH with the main purpose to confirm or exclude the autonomous hyperinsulinemia (AH; insulinoma): determination the capillary beta-hydroxybutyrate (BHB) during prolonged fasting test (FT), and glucagon test (GT) at the moment of hypoglycemia. GT is more labor-intensive, high-cost and lead to potential complications. Therefore, we assumed that ...

Introduction: Hashimoto’s thyroiditis (HT) is multifactorial disease, caused by a complex interplay of genetic, hormonal, and environmental influences that provoke the development of inappropriate immune responses against thyroid on multiple levels and the initiation of a long-standing autoimmune reaction. Interaction between cellular and humoral immunity is base of HT’s pathogenesis. Our research focuses on the functional activity and the quantity of T regulatory an...

Objectives: to modify the classification of autoimmune adrenal insufficiency (AAI).Methods: n=8 patients with early stages (potential and latent) of AAI were included (table 1).Results: Based on the analysis of clinical and laboratory data of patients, a modified classification of AAI has been developed (table 2).Table 1. Characteristics of patient...

Background: During pregnancy, the physiology of the thyroid gland undergoes important changes. As a result, change levels of thyroid hormones. In the latest clinical guidelines, experts have recommended to perform population-based studies to determine reference intervals for thyroid hormones.Aim: To evaluate the reference intervals of free thyroxine in different trimesters of pregnancy in women living in regions with mild iodine deficiency.<p class="...

Introduction: In Russia, full-scale studies aimed at assessing the incidence of endocrine autoimmune diseases (eAID) in adult patients with vitiligo have not been conducted.Objectives: analysis of occurrence of eAID in patients with vitiligo.Methods: 1) The first part of the study included 39 patients aged 19-73 years with endocrine pathology and vitiligo, who were initially examined in Endocrinology Research Centre. 2)The second p...

Purpose: To assess the level of biomarkers of early kidney damage (urinary and plasma cystatin C) in patients with prediabetes and to characterize their association with risk factors for the development of nephropathy.Materials and methods: The object of the study were 60 patients (32% men, 68% women) with early disorders of carbohydrate metabolism (impaired fasting glycemia (IFG) and impaired carbohydrate tolerance (IGT), WHO criteria, 2009). The mean a...

Introduction: Research into autoimmune disorders associated with COVID-19 in the middle of an ongoing COVID-19 pandemic is an important and urgent challenge. We focus on the potential relationship between coronavirus infection and other autoimmune diseases, and the positive therapeutic effect of the treatment of severe forms of COVID-19 with drugs traditionally used in the treatment of rheumatological diseases. The results of this study are a starting point for understanding t...

Purpose: To study the frequency of polymorphic alleles and genotypes of the PPARG (rs 1801282) gene and its effect on carbohydrate and lipid metabolism in patients with prediabetes.Materials and methods: The object of the study were 60 patients (32% men, 68% women) with early disorders of carbohydrate metabolism (WHO criteria, 2009). The mean age was 44.3 &pm; 7.8 years. The average value of fasting glycemia - 5.7&pm;0.42 mmol/l, the average level of gly...